Tyranny of biochemistry

The tyranny of biochemistry is a social concept, used to refer to major biochemical functions that take place in the brain. Because of their uncontrollable nature and primitive background, they are universally hated by the Homelanders.

Overview
Biochemistry plays a crucial role in any living organism, aimed to protect, regulate and ensure procreation of said organism.

When the Homelanders were actively studying biology and anatomy, the discovery of biochemistry and its function became a nasty surprise to all of them. They couldn't stand the idea that so many important functions are controlled by a primitive biological system, which is barely able to be altered by cognitive efforts.

They couldn't call themselves sapient until this system was literally ruling them, defining their behavior, attitude, hormonal background and other things.

Creation of the romancezone concept became the last straw, and the Homelanders launched one of their most ambitious and important project in the history of Home -- 'The end of the tyranny of biochemistry.'

Pre-uploading
Before uploading their minds, the Homelanders were forced to use various chemical substances, tested on dummies. These substances allowed them to temporarely stop or slow down a number of biochemical functions, primarily those that affect sexual behavior and attractiveness.

Despite the difficulties and failures this period is known to be the time of great medical discoveries and technologies, primarily aimed to put biochemistry under control and to prevent or treat all possible consequences of such control.

Post-uploading
Mind uploading had solved all the issues once and for all, pretty much finishing the project and ending the tyranny of biochemistry.

The organic brain part which every Homelander has and which responds for emotions, hormones and similar things is under the full control of the artificial intelligence. It is usually allowed to function without major alterings, but such things as aggressiveness,instinctual attractiveness, also know as love from the first sight, and some other functions had been cut off a long time ago.

A Homelander can feel anger or hatred, but it is no longer a product of the primal evolutionary traits, but the cold and objective artificial intelligence. Anger doesn't make them lose their self-control and doesn't impair their judgement; instead, it became a quite effective and powerful tool.

Current state
Today, all the Homelanders are able to control their biochemical functions, from simple to more complex. They can control the feelings of thirst, hunger, pain, fear, sexual tension and many others just as well as they can alter or diminish their preferences, including mating ones.

Ending the tyranny of biochemistry is one of the mandatory conditions for a species to become truly sapient. If any species, instead of fighting the tyranny will try to accept it and live with it, it severely lowers a chance to achieve sapience.